Azidothymidine

• Catalog number
  B1113-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  3'-Azido-3'-deoxythymidine; AZT; Zidovudine
• Description
  Azidothymidine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC₅₀ = 3 nM) with low cytotoxicity (CC₅₀ > 5 μM). Displays 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency.
• CAS Number
  30516-87-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₀H₁₃N₅O₄
• Molecular Weight
  267.24
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml) or H2O (>10 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A nucleoside reverse transcriptase inhibitor and homology directed repair (HDR) blocker
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00006536
• PubChem CID
  35370
• PubChem CID Link
• SMILES
  CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
• InChi
  InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
• InChi Key
  HBOMLICNUCNMMY-XLPZGREQSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Azidothymidine  
• Short name
  Azidothymidine
• Alternative name
  Azidothymidine

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