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Stock availabilitIn Stock
In Stock
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CAS number
319460-85-0
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Description
VEGFR kinase inhibitor
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Molecular weight
386,5 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
AG-013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide, N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C22H18N4OS
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Origin
Synthetic
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Purity pourcentage
≥98% (HPLC)
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Soluble in
Soluble to 25 mM in DMSO
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Physical appearance
White to tan powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H410 Very toxic to aquatic life with long lasting effects Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P330 Rinse mouth. P391 Collect spillage. P501 Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
6450551
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Scientific context
Axitinib is a potent and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. It has also been shown to inhibit PDGFR-β and c-Kit.
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Bibliography
1. Hu-Lowe D.D., et al. (2008) Clin. Cancer Res: J. Am. Ass. Cancer Res. 14(22): 7272–7283.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Axitinib (SIH-494), a VEGFR kinase inhibitor. CAS #: 319460-85-0. Molecular Formula: C22H18N4OS. Molecular Weight: 386.5 g/mol. Chemical structure of Axitinib, a VEGFR kinase inhibitor (SIH-494). CAS # 319460-85-0. Molecular Formula: C22H18N4OS.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
