ATM Kinase Inhibitor, KU-55933

• Catalog number
  1685-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
• Description
  A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
• CAS Number
  587871-26-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₇NO₃S₂
• Molecular Weight
  395.49
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  DMSO (100 mM) and Ethanol (50 mM)
• Handling
  Protect from air and light
• Tag Line
  An ATM kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD08276985
• PubChem CID
  5278396
• PubChem CID Link
• SMILES
  C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
• InChi
  InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
• InChi Key
  XRKYMMUGXMWDAO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  ATM   Kinase   Inhibitor   KU-55933  
• Gene symbol
  ARMC9, ATM
• Short name
  ATM Kinase Inhibitor, KU-55933
• Alternative name
  ataxia telangiectasia mutated phosphorylation catalyst suppressor, KU-55933
• Alternative to gene target
  ataxia telangiectasia mutated, AT1 and ATA and ATC and ATD and ATDC and ATE and TEL1 and TELO1, ATM and IDBG-70193 and ENSG00000149311 and 472, transferase activity, nuclei, Atm and IDBG-165511 and ENSMUSG00000034218 and 11920, ATM and IDBG-629882 and ENSBTAG00000003111 and 526824

Gene info

• Identity
  HGNC:20730
• Gene
  ARMC9
• Long gene name
  armadillo repeat containing 9
• Synonyms
  • FLJ12584
  • KIAA1868
  • ARM
  • KU-MEL-1
• GenBank acession
  • BC004514
• Locus
  2q37.1
• Discovery year
  2005-10-04
• Entrez gene record
  80210
• Pubmed identfication
  • 11347906
• RefSeq identity
  • NM_025139
• Classification
  • Armadillo repeat containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133229

Gene info

• Identity
  HGNC:795
• Gene
  ATM
• Long gene name
  ATM serine/threonine kinase
• Synonyms gene
  • ATA
  • ATDC
  • ATC
  • ATD
• Synonyms gene name
  • ataxia telangiectasia mutated (includes complementation groups A, C and D)
  • ataxia telangiectasia mutated
• Synonyms
  • TEL1
  • TELO1
• Synonyms name
  • TEL1, telomere maintenance 1, homolog (S. cerevisiae)
• GenBank acession
  • AB209133
• Locus
  11q22.3
• Discovery year
  1995-07-07
• Entrez gene record
  472
• RefSeq identity
  • NM_000051
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000166480
• Locus Specific Databases
  • Ataxia Telangiectasia Mutated (ATM)
  • Global Variome shared LOVD
  • LRG_135

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