APXL Antibody
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Catalog numberbs-12131R
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PricePlease ask
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Size0.1ml
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Long nameAPXL Primary Polyclonal Antibody
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Also known asAPXL PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenAPXL
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SpecificityThis is a highly specific antibody against APXL.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APXL
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenAPXL is a 1,616 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, the cytoskeleton, the cell junction and the apical cell membrane. Containing one ASD1 domain, one ASD2 domain and one PDZ domain, APXL interacts with F-Actin and is thought to mediate endothelial cell morphology during cell spreading, possibly regulating melanosome biogenesis and inducing γ Tubulin redistribution. APXL is expressed in kidney, brain, lung, pancreas and placenta and is overexpressed in melanomas, suggesting a role in tumor transformation and metastasis. The gene encoding APXL maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesApical like protein; Apical like protein APXL protein; apical protein of Xenopus-like; Apical protein Xenopus laevis like; apical protein, Xenopus laevis-like; apical protein-like; apical protein-like Xenopus laevis; Apical-like protein; APX homolog of Xenopus; C630003H05Rik; DKFZp781J074; FLJ39277; HSAPXL; Liver regeneration-related protein LRRG167; Protein Apxl; Protein Shroom2; Shrm2; SHRM2_HUMAN; SHROOM 2; Shroom family member 2; shroom2.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolSHROOM2
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Short nameAnti-APXL
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameAPXL Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameshroom family member 2
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Synonyms gene
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Synonyms gene name
- apical protein, Xenopus laevis-like
- apical protein-like (Xenopus laevis)
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GenBank acession
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Locus
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Discovery year1995-06-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Shroom family
- PDZ domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data