APEX2 Antibody

• Catalog number
  bs-6587R
• Price
  Please ask
• Size
  0.1ml

• Long name
  APEX2 Primary Polyclonal Antibody
• Also known as
  APEX2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  APEX2
• Specificity
  This is a highly specific antibody against APEX2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  300-350/518
• Subcellular location
  Cytoplasm, Nucleus, Mitochondrion
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APEX2
• Gene ID number
  27301
• Swiss Prot
  Q9UBZ4
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  APE2; XTH2; ZGRF2; APEXL2; DNA-(apurinic or apyrimidinic site) lyase 2; AP endonuclease XTH2; APEX nuclease 2; APEX nuclease-like 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2; APEX2
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  APEX2  
• Gene symbol
  APEX2
• Short name
  Anti-APEX2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  APEX2 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17889
• Gene
  APEX2
• Long gene name
  apurinic/apyrimidinic endodeoxyribonuclease 2
• Synonyms gene name
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2
• Synonyms
  • APEXL2
  • APE2
  • XTH2
  • ZGRF2
• Synonyms name
  • zinc finger, GRF-type containing 2
• GenBank acession
  • AB021260
• Locus
  Xp11.21
• Discovery year
  2002-07-22
• Entrez gene record
  27301
• Pubmed identfication
  • 11376153
• Classification
  • Zinc fingers GRF-type
• VEGA ID
  OTTHUMG00000021642
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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