UCHL5 Antibody

• Catalog number
  6129-50
• Price
  Please ask
• Size
  50 μg

• Antibody Target
  UCHL5
• Target Alternative Name
  AD-019, CGI-70, Ubiquitin carboxyl-terminal hydrolase isozyme L5, Ubiquitin C-terminal hydrolase, UCH37, Ubiquitin thioesterase L5, UCH37, UCH-L5, (Ubiquitin C-terminal hydrolase L5
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant full length protein
• Accession
  Q9Y5K5
• Gene Id
  51377
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  50 µg of antibody in PBS containing 10% glycerol
• Purification
  Purified from egg yolk
• Application
  Western blot
• Application And Usages
  Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 μg/mL
• Description
  Protein ubiquitination and deubiquitination are reversible processes catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (DUBs). DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. UCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all possess a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL5 and BAP1 have unique extended C-terminal tails. UCHL5 is the only ubiquitin carboxy-terminal hydrolase (UCH)-family protease that is associated with mammalian proteasomes. It is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. It is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regulatory complex.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  UCHL5  
• Gene symbol
  UCHL5
• Short name
  UCHL5 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Chicken IgG
• Alternative name
  ubiquitin carboxyl-terminal hydrolase L5 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  ubiquitin carboxyl-terminal hydrolase L5, UCHL5 and IDBG-105454 and ENSG00000116750 and 51377, proteasome binding, nuclei, Uchl5 and IDBG-197081 and ENSMUSG00000018189 and 56207, UCHL5 and IDBG-629660 and ENSBTAG00000013620 and 282110

Gene info

• Identity
  HGNC:19678
• Gene
  UCHL5
• Long gene name
  ubiquitin C-terminal hydrolase L5
• Synonyms gene name
  • ubiquitin carboxyl-terminal hydrolase L5
• Synonyms
  • UCH37
  • CGI-70
  • INO80R
• Synonyms name
  • INO80 complex subunit R
• Locus
  1q31.2
• Discovery year
  2002-11-11
• Entrez gene record
  51377
• Pubmed identfication
  • 10810093
  • 16027725
• RefSeq identity
  • NM_015984
• Classification
  • Ubiquitin C-terminal hydrolases
  • INO80 complex
• VEGA ID
  OTTHUMG00000035561

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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