anti-UCHL1 Antibody

anti-UCHL1 Antibody is available 1 time from Biovision labs

6130-50 | anti-UCHL1 Antibodysize: UCHL1 Antibody | 235.48 USD

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  • Target of this antibody:
    UCHL1
  • Alternative names of antibody target:
    Neuron cytoplasmic protein 9.5, PARK5, PGP9.5, PGP 9.5, Ubiquitin carboxyl-terminal, hydrolase isozyme L1, Ubiquitin thioesterase L1, UCH-L1, Ubiquitin thioesterase L1.
  • Background information:
    Protein ubiquitination and Deubiquitination are reversible processes catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (DUBs). DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. UCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all possess a conserved catalytic domain (UCH domain) of about 230 amino acids. Although UCHL1 and UCHL3 are the most closely related UCH family members with about 53% identity, their biochemical properties differ in that UCHL1 binds monoubiquitin and UCHL3 shows dual specificity toward both ubiquitin (Ub) and NEDD8, a Ub-like molecule. UCHL1 (PGP9.5) is a 25 kDa protein; it is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It comprises >1% of total brain protein but is almost absent from other tissues. It has been implicated both in Parkinson’s disease and in lung cancer.
  • Antibody host:
    Chicken
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Chicken IgG
  • This antibody reacts with:
    Human
  • Immunogene sequence:
    Recombinant full length protein
  • Concentration of antibody:
    N/A
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    50 µg of antibody in PBS containing 10% glycerol
  • Purification method:
    Purified from egg yolk
  • This antibody has been succesfully tested for use in following methods:
    Western blot
  • Recommended usage:
    Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 μg/mL
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-UCHL1 Antibody
  • Technique
    Antibody, anti
  • Alternative name
    antibody to-UCHL1 (Antibody to)
  • Alternative technique
    antibodies
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