anti-TXNIP Antibody

• Catalog number
  7941
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).
• Gene names
  Thioredoxin-interacting protein, BMP and activin membrane-bound inhibitor homolog, non-metastatic gene A protein, NMA
• Antibodie s label
  unlabelled serum
• Purity
  TXNIP antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  TXNIP antibody is human, mouse and rat reactive.
• Antigen
  TXNIP antibody was made against a 16 amino acid peptide near the center of human TXNIP
• Immuno application
  ELISA, Western Blot
• Antibody advice
  TXNIP body can be used for detection of TXNIP by Western blot at 0.5 - 1 ug/ml.
• Suspention pH azide
  TXNIP antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  TXNIP antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  171184421
• Ncbi nr
  NP_006463
• KDa
  Predicted: 43 kDa Observed: 39 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  10628
• GENE symbol
  TXNIP
• Antigene name
  thioredoxin interacting protein
• Source
  homo sapiens
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TXNIP  
• Gene symbol
  TXNIP
• Short name
  anti-TXNIP Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toTXNIP (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16952
• Gene
  TXNIP
• Long gene name
  thioredoxin interacting protein
• Synonyms
  • VDUP1
  • EST01027
  • HHCPA78
  • THIF
  • ARRDC6
• Synonyms name
  • upregulated by 1,25-dihydroxyvitamin D-3
  • thioredoxin binding protein 2
• GenBank acession
  • S73591
• Locus
  1q21.1
• Discovery year
  2001-12-12
• Entrez gene record
  10628
• Pubmed identfication
  • 8086474
• RefSeq identity
  • NM_006472
• Classification
  • Alpha arrestins
• VEGA ID
  OTTHUMG00000013755

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products