Tuberin Antibody, ALEXA FLUOR 594
-
Catalog number
bs-3586R-A594
-
Price
Please ask
-
Size
100ul
-
-
Long name
Tuberin Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
-
Also known as
Anti-Tuberin PAb ALEXA FLUOR 594
-
Category
Conjugated Primary Antibodies
-
Conjugated with
ALEXA FLUOR® 594
-
Host Organism
Rabbit (Oryctolagus cuniculus)
-
Target Antigen
Tuberin
-
Specificity
This is a highly specific antibody against Tuberin.
-
Modification
Unmodified
-
Modification Site
None
-
Clonality
Polyclonal
-
Clone
Polyclonal antibody
-
Concentration
1ug per 1ul
-
Immunogen range
1600-1650/1809
-
Subcellular location
Cytoplasm
-
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tuberin
-
Gene ID Number
7249
-
Swiss Prot
P49815
-
Tested applications
IF(IHC-P)
-
Recommended dilutions
IF(IHC-P)(1:50-200)
-
Crossreactivity
Human, Mouse, Rat
-
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the antigen
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
-
Purification
Purified by Protein A.
-
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
-
Excitation emission
590nm/617nm
-
Synonyms
LAM; TSC4; PPP1R160; Tuberin; Tuberous sclerosis 2 protein; TSC2
-
Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Conjugation
Alexa Fluor, ALEXA FLUOR® 594
-
Conjugated
Alexa conjugate 1
-
French translation
anticorps
-
Gene target
-
Gene symbol
TSC2, RALGAPA1
-
Short name
Anti-Tuberin
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
Immunoglobulin G (IgG)
-
Label
ALEXA FLUOR 594
-
Alternative name
Tuberin Polyclonal Antibody, ALEXA FLUOR 594
-
Alternative technique
antibodies
-
Gene info
-
Identity
-
Gene
-
Long gene name
TSC complex subunit 2
-
Synonyms gene
-
Synonyms gene name
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
1989-05-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- TSC complex
- Armadillo like helical domain containing
- Protein phosphatase 1 regulatory subunits
-
VEGA ID
-
Locus Specific Databases
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products