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Gene info
TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
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Gene names
TSLP Receptor Antibody: CRLM2, Ly114, Tpte2, Tslpr, Crlm2, Cytokine receptor-like factor 2, Cytokine receptor-like molecule 2, CRLM-2
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Antibodie s label
unlabelled serum
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Purity
TSLP Receptor Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Antigen
TSLP Receptor antibody was made against a 19 amino acid synthetic peptide from near the center of human TSLP receptor.
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
TSLP-R antibody can be used for detection of TSLP-R by Western blot at 0.5 - 1 ug/mL. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azide
TSLP Receptor Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
TSLP Receptor antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human
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Omim nr
31980663
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Ncbi nr
NP_057924
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
57914
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GENE symbol
Crlf2
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Antigene name
cytokine receptor-like factor 2
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Source
Mus musculus
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Protein nr
Q8CII9
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
