TPX2 Antibody

• Catalog number
  3755-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  TPX2
• Target Alternative Name
  TPX2, TPX-2, Microtubule-associated protein TPX2 homolog, DIL2, DIL-2, Differentially expressed in lung cells, HCA519, Hepatocellular carcinoma-associated antigen 519, REPP86, Restricted expression proliferatio
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Synthetic peptide from human TPX2
• Accession
  Q9ULW0
• Gene Id
  22974
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  100 µl purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot, Immunoprecipitation
• Application And Usages
  Western blotting (1:500 – 1:2000) and Immunoprecipitation. However, the optimal concentrations should be determined individually. The antibody recognizes the human TPX2. Reactivity to other species has not been tested.
• Description
  TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase. Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly. TPX2 appears to play a structural role in spindle formation. TPX2 activates Eg2 in a microtubule-dependent manner by stimulating the phosphorylation and kinase activity of Eg2. TPX2 is inactivated by binding to importin a, a nuclear import factor. Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TPX2  
• Gene symbol
  TPX2
• Short name
  TPX2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  TPX2, microtubule-associated, homolog (Xenopus laevis) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  TPX2, microtubule-associated, homolog (Xenopus laevis), C20orf1 and C20orf2 and DIL-2 and DIL2 and FLS353 and GD:C20orf1 and HCA519 and HCTP4 and p100 and REPP86, TPX2 and IDBG-63816 and ENSG00000088325 and 22974, protein kinase binding, nuclei, Tpx2 and IDBG-209892 and ENSMUSG00000027469 and 72119, BT.28741 and IDBG-641544 and ENSBTAG00000018775 and 507226

Gene info

• Identity
  HGNC:1249
• Gene
  TPX2
• Long gene name
  TPX2 microtubule nucleation factor
• Synonyms gene
  • C20orf2
  • C20orf1
• Synonyms gene name
  • chromosome 20 open reading frame 1
  • TPX2, microtubule-associated, homolog (Xenopus laevis)
  • TPX2, microtubule-associated
• Synonyms
  • p100
  • DIL-2
• GenBank acession
  • AF098158
• Locus
  20q11.21
• Discovery year
  1999-09-29
• Entrez gene record
  22974
• Pubmed identfication
  • 9207457
  • 10393424
• VEGA ID
  OTTHUMG00000032190

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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