Anti-TPP1 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-8528R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  TPP1
• Specificity
  This antibody reacts specifically with TPP1
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human TPP1/CLN2
• Gene ID
  1200
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  Cell growth inhibiting gene 1 protein; Cell growth-inhibiting gene 1 protein; Ceroid lipofuscinosis neuronal 2; Ceroid lipofuscinosis neuronal 2 late infantile Jansky Bielschowsky disease; Ceroid lipofuscinosis neuronal 2 late infantile antibody CLN 2; CLN2; CLN-2; GIG 1; GIG1; Growth inhibiting protein 1; LPIC; Lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; TPP 1; TPP I; TPP-1; TPP-I; Tpp1; TPP1_HUMAN; TPPI; Tripeptidyl aminopeptidase; Tripeptidyl peptidase I; Tripeptidyl-peptidase 1; Tripeptidyl-peptidase I.
• Also known as
  TPP1 Polyclonal Antibody
• Other name
  Anti-TPP1 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  TPP1  
• Gene symbol
  ACD, TPP1
• Short name
  Anti-TPP1
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  TPP1 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:25070
• Gene
  ACD
• Long gene name
  ACD shelterin complex subunit and telomerase recruitment factor
• Synonyms gene name
  • adrenocortical dysplasia homolog (mouse)
• Synonyms
  • Ptop
  • Pip1
  • Tpp1
  • Tint1
• Synonyms name
  • TIN2 interacting protein 1
  • POT1 and TIN2 organizing protein
• GenBank acession
  • AF070535
• Locus
  16q22.1
• Discovery year
  2005-01-04
• Entrez gene record
  65057
• Pubmed identfication
  • 15231715
  • 15181449
• RefSeq identity
  • NM_022914
• Classification
  • Shelterin complex
• VEGA ID
  OTTHUMG00000137547
• Locus Specific Databases
  • LRG_1237

Gene info

• Identity
  HGNC:2073
• Gene
  TPP1
• Long gene name
  tripeptidyl peptidase 1
• Synonyms gene
  • CLN2
  • SCAR7
• Synonyms gene name
  • ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)
  • spinocerebellar ataxia, autosomal recessive 7
  • tripeptidyl peptidase I
• Synonyms
  • LPIC
  • TPP-1
• Synonyms name
  • TPP I
  • lysosomal pepstatin-insensitive carboxypeptidase
• GenBank acession
  • AF017456
• Locus
  11p15.4
• Discovery year
  1990-01-30
• Entrez gene record
  1200
• Pubmed identfication
  • 9653647
  • 23418007
• VEGA ID
  OTTHUMG00000133404
• Locus Specific Databases
  • Neuronal Ceroid Lipofuscinoses; NCL Mutations
  • LRG_830

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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