anti-TP53BP1 Antibody

• Catalog number
  48-864
• Price
  Please ask
• Size
  0.025 mL

• Gene info
  P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. Tumor protein p53 binding protein 1 binds to the central domain of p53 required for site-specific DNA binding thus inhibiting the ability of p53 to bind DNA. TP53BP1 also functions as a checkpoint protein with properties of a DNA double-strand break sensor. It is a putative substrate of ATM kinase and is phosphorylated in response to DNA damage and localizes to sites of double-strand breaks.
• Gene names
  TP53BP1, 53BP1, p202, p53-binding protein 1, p53-binding protein 53bp1, p53BP1
• Antibodie s label
  unlabelled serum
• Purity
  Affinity Chromatography
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  TP53BP1 antibody was made against a synthetic peptide corresponding to the carboxy - terminus of TP53BP1 (Human).
• Immuno application
  Western Blot, immuno-histo-chemistry
• Antibody advice
  TP53BP1 antibody can be used in ELISA, and immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  PBS, pH 7.2, no preservatives added.
• Keep at
  Aliquot and store TP53BP1 antibody at -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  8928568
• Ncbi nr
  Q12888
• Vial with antibody
  in solution
• NCBI GENE nr
  7158
• GENE symbol
  TP53BP1
• Antigene name
  tumor protein p53 binding protein 1
• Source
  Homo sapiens
• Protein nr
  Q12888
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TP53BP1  
• Gene symbol
  TP53BP1
• Short name
  anti-TP53BP1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toTP53BP1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11999
• Gene
  TP53BP1
• Long gene name
  tumor protein p53 binding protein 1
• Synonyms gene name
  • tumor protein p53-binding protein, 1
• Synonyms
  • 53BP1
  • p202
  • TDRD30
• GenBank acession
  • U09477
• Locus
  15q15.3
• Discovery year
  2000-06-24
• Entrez gene record
  7158
• Pubmed identfication
  • 8016121
  • 9748285
• Classification
  • Tudor domain containing
• VEGA ID
  OTTHUMG00000059757

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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