anti-TMP21 Antibody

• Catalog number
  3999
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta; production, demonstrating that TMP21 can modulate gamma-secretase activity.
• Gene names
  TMP21 Antibody: p23, TMP21, S31I125, Tmp-21-I, S31III125, P24(DELTA), Transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane-trafficking protein
• Antibodie s label
  unlabelled serum
• Purity
  TMP21 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  TMP21 antibody was made against a 18 amino acid synthetic peptide from near the center of human TMP21.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry
• Antibody advice
  TMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  TMP21 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  TMP21 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  4885697
• Ncbi nr
  AAD31941
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  10972
• GENE symbol
  TMED10
• Antigene name
  transmembrane emp24-like trafficking protein 10 (yeast)
• Source
  Homo sapiens
• Protein nr
  P49755
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TMP21  
• Gene symbol
  TMED10P1, TMED10
• Short name
  anti-TMP21 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toTMP21 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:30754
• Gene
  TMED10P1
• Long gene name
  transmembrane p24 trafficking protein 10 pseudogene 1
• Synonyms gene
  • TMED10P
• Synonyms gene name
  • transmembrane emp24-like trafficking protein 10 (yeast) pseudogene
  • transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 1
• Synonyms
  • Tmp21-II
• GenBank acession
  • AJ004914
• Locus
  8q24.3
• Discovery year
  2005-08-26
• Entrez gene record
  286102
• Pubmed identfication
  • 10376215
• RefSeq identity
  • XR_002807
• VEGA ID
  OTTHUMG00000165203

Gene info

• Identity
  HGNC:16998
• Gene
  TMED10
• Long gene name
  transmembrane p24 trafficking protein 10
• Synonyms gene name
  • transmembrane emp24-like trafficking protein 10 (yeast)
• Synonyms
  • TMP21
  • P24(DELTA)
  • p24d1
  • p24delta1
  • p23
• GenBank acession
  • AL832012
  • X97442
• Locus
  14q24.3
• Discovery year
  2005-08-26
• Entrez gene record
  10972
• Pubmed identfication
  • 7596406
  • 8663407
• RefSeq identity
  • NM_006827
• Classification
  • Transmembrane p24 trafficking proteins
• VEGA ID
  OTTHUMG00000171771

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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