anti-TLR8 Antibody [44C143]

• Catalog number
  49-799
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa (4,5). Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
• Gene names
  TLR8, CD288, Toll-like receptor 8, CD288 antigen
• Antibodie s label
  unlabelled serum
• Purity
  Protein G Column
• Ab raised in
  Mouse
• Type
  Monoclonal
• Monoclonal
  [44C143]
• Immunoglobulin
  IgG,k
• Antigen
  TLR8 monoclonal antibody was made against amino acids 750 - 850 of TLR8 (Human).
• Immuno application
  Western Blot, immuno-histo-chemistry, FLOW
• Antibody advice
  TLR8 antibody can be used in immunohistochemistry starting at 1:100, and flow cytometry.
• Suspention pH azide
  0.2 ml PBS, 0.05% BSA, 0.05% sodium azide.
• Keep at
  Store TLR8 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human, Mouse
• Omim nr
  20140873
• Ncbi nr
  Q9NR97
• Vial with antibody
  in solution
• NCBI GENE nr
  51311
• GENE symbol
  TLR8
• Antigene name
  toll-like receptor 8
• Source
  Homo sapiens
• Protein nr
  Q9NR97
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TLR8   [44C143]  
• Gene symbol
  TLR8-AS1, TLR8
• Short name
  anti-TLR8 Antibody [44C143]
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toTLR8 (antibody to-) [44C143]
• Alternative technique
  antibodies
• Alternative to gene target
  toll-like receptor 8, TLR8 and IDBG-44288 and ENSG00000101916 and 51311, drug binding, Plasma membranes, Tlr8 and IDBG-185523 and ENSMUSG00000040522 and 170744

Gene info

• Identity
  HGNC:40720
• Gene
  TLR8-AS1
• Long gene name
  TLR8 antisense RNA 1
• Synonyms gene name
  • TLR8 antisense RNA 1 (non-protein coding)
• Locus
  Xp22.2
• Discovery year
  2011-07-29
• Entrez gene record
  349408
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000021142

Gene info

• Identity
  HGNC:15632
• Gene
  TLR8
• Long gene name
  toll like receptor 8
• Synonyms gene name
  • toll-like receptor 8
• Synonyms
  • CD288
  • hTLR8
• GenBank acession
  • AF246971
• Locus
  Xp22.2
• Discovery year
  2001-04-27
• Entrez gene record
  51311
• Pubmed identfication
  • 11022119
• RefSeq identity
  • NM_016610
• Classification
  • Toll like receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000021145
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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