anti-Thyroid Hormone Receptor Antibody [2103]

  • Catalog number
    50-170
  • Price
    Please ask
  • Size
    0.1 mL
  • Gene info
    Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
  • Gene names
    AR7, EAR7, ERBA, CHNG6, ERBA1, NR1A1, THRA1, THRA2, ERB-T-1, c-ERBA-1, Nuclear receptor subfamily 1 group A member 1, EAR-7
  • Antibodie s label
    unlabelled serum
  • Purity
    Protein G purified
  • Ab raised in
    Mouse
  • Type
    Monoclonal
  • Monoclonal
    2103
  • Immunoglobulin
    IgG1
  • Antigen
    Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a1/a2-isotype.
  • Immuno application
    Western Blot
  • Antibody advice
    The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with canine, mouse and rat based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
  • Suspention pH azide
    100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
  • Keep at
    Thyroid Hormone Receptor antibody can be stored at -20 grades C and is stable at -20 grades C for at least 1 year.
  • Works with
    Human, Mouse, Rat, Dog
  • Omim nr
    135705
  • Ncbi nr
    P10827
  • KDa
    50/58
  • Vial with antibody
    in solution
  • NCBI GENE nr
    7067
  • GENE symbol
    THRA
  • Antigene name
    thyroid hormone receptor, alpha
  • Source
    Homo sapiens
  • Protein nr
    P10827
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Hormone releasing factors and releasing hormones are  signaling molecules produced by glands in multicellular organisms. The glands that secrete Luteinizing hormones LHRG and LH, FSH comprise the endocrine signaling system. The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signaling). Human recombinant LHRG and GHRH are produced in E. coli or in yeast cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-Thyroid Hormone Receptor Antibody [2103]
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toThyroid Hormone Receptor (antibody to-) [2103]
  • Alternative technique
    antibodies
  • Tissue
    thyroid
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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