anti-SPTLC1 Antibody

• Catalog number
  26-155
• Price
  Please ask
• Size
  50 ug

• Gene info
  Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
• Gene names
  SPTLC1, HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by peptide affinity chromatography method.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SPTLC1.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  SPTLC1 antibody can be used for detection of SPTLC1 by ELISA at 1:62500. SPTLC1 antibody can be used for detection of SPTLC1 by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
• Suspention pH azide
  Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
• Keep at
  For short periods of storage (days) store at 4 grades C. For longer periods of storage, store SPTLC1 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
• Works with
  Human, Mouse, Rat
• Omim nr
  5454084
• Ncbi nr
  NP_006406
• KDa
  53 kDa
• Vial with antibody
  Lyophilized
• Quantity per ml
  1 mg/ml
• NCBI GENE nr
  10558
• GENE symbol
  SPTLC1
• Antigene name
  serine palmitoyltransferase, long chain base subunit 1
• Source
  Homo sapiens
• Protein nr
  O15269
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SPTLC1  
• Gene symbol
  SPTLC1
• Short name
  anti-SPTLC1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSPTLC1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11277
• Gene
  SPTLC1
• Long gene name
  serine palmitoyltransferase long chain base subunit 1
• Synonyms gene
  • HSN1
• Synonyms gene name
  • hereditary sensory neuropathy, type 1
• Synonyms
  • LCB1
  • SPTI
  • HSAN1
  • hLCB1
• GenBank acession
  • Y08685
• Locus
  9q22.31
• Discovery year
  2000-07-31
• Entrez gene record
  10558
• Pubmed identfication
  • 9363775
• RefSeq identity
  • NM_006415
• VEGA ID
  OTTHUMG00000021047
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_272

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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