anti-SPG15 Antibody
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Catalog number5023
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoSPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.
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Gene namesSPG15 Antibody: SPG15, FYVE-CENT, KIAA0321, Zinc finger FYVE domain-containing protein 26, FYVE domain-containing centrosomal protein
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Antibodie s labelunlabelled serum
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PuritySPG15 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenSPG15 antibody was made against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15.
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Immuno applicationELISA, Western Blot, immuno fluorescence
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Antibody adviceSPG15 antibody can be used for detection of SPG15 by Western blot at 0.5 - 1 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azideSPG15 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atSPG15 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr119601358
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Ncbi nrEAW80952
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr23503
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GENE symbolZFYVE26
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Antigene namezinc finger, FYVE domain containing 26
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SourceHomo sapiens
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Protein nrQ68DK2
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolZFYVE26
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Short nameanti-SPG15 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toSPG15 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namezinc finger FYVE-type containing 26
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Synonyms gene
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Synonyms gene name
- spastic paraplegia 15 (complicated, autosomal recessive)
- zinc finger, FYVE domain containing 26
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-04-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers FYVE-type
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
