anti-SKA2 Antibody

• Catalog number
  5403
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  SKA2 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
• Gene names
  SKA2 Antibody: FAM33A, FAM33A, Spindle and kinetochore-associated protein 2, Protein FAM33A
• Antibodie s label
  unlabelled serum
• Purity
  SKA2 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  SKA2 antibody was made against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  SKA2 antibody can be used for detection of SKA2 by Western blot at 0.5 - 1 ug/mL.
• Suspention pH azide
  SKA2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  SKA2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse
• Omim nr
  32699054
• Ncbi nr
  NP_872426
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  348235
• GENE symbol
  SKA2
• Antigene name
  spindle and kinetochore associated complex subunit 2
• Source
  Homo sapiens
• Protein nr
  Q8WVK7
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SKA2  
• Gene symbol
  SKA2
• Short name
  anti-SKA2 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSKA2 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:28006
• Gene
  SKA2
• Long gene name
  spindle and kinetochore associated complex subunit 2
• Synonyms gene
  • FAM33A
• Synonyms gene name
  • family with sequence similarity 33, member A
• Synonyms
  • FLJ12758
• GenBank acession
  • BC017873
• Locus
  17q23.2
• Discovery year
  2004-02-24
• Entrez gene record
  348235
• Pubmed identfication
  • 17093495
  • 19289083
  • 18583474
• RefSeq identity
  • NM_182620
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000179361

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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