SIRT2 Antibody

  • Catalog number
    6138-100
  • Price
    Please ask
  • Size
    100 μg
  • Antibody Target
    SIRT2
  • Target Alternative Name
    SIRT2, SIR2, SIR2L, SIR2L2
  • Antibody Type
    Polyclonal
  • Species Reactivities
    Human, mouse, rat
  • Immunogen Sequence
    C terminal peptide of human SIRT2
  • Accession
    Q8IXJ6
  • Gene Id
    22933
  • Appearance
    Colorless liquid
  • Form
    Liquid
  • Formulation
    100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
  • Purification
    Affinity purified
  • Application
    Western blot, Immunohistochemistry
  • Positive Control
    Western Blot: Brain tissue extracts
  • Application And Usages
    Western blot: 1:500 – 1:2000 dilution, IHC: 1:50 - 1:200 dilution. However, the optimal conditions should be determined individually.
  • Description
    The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. This SIRT family of genes is highly conserved from prokaryotes to eukaryotes and is involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. SIRT2, a human homolog of the yeast SIR2 (silent information regulator­2), functions as transcriptional silencing mediator at mating­type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G (2)/M transition of the cell cycle. SIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G (2), during M, and into the period of cytokinesis. Inhibition of SIRT2 is reported to rescue alpha­synuclein toxicity and modify inclusion morphology in a cellular model of Parkinson's disease.
  • Storage Condition
    -20 °C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • Usage
    For Research Use Only! Not to be used in humans.
  • Handling
    The antibody solution should be gently mixed before use.
  • Western Blot Verified
    Verified
  • Immunocytochemistry Verified
    Verified
  • Immunofluorescence Verified
    Not Verified
  • Immunoprecipitation Verified
    Not Verified
  • ELISA Verified
    Not Verified
  • ChIP Verified
    Not Verified
  • Flow Cytometry Verified
    Not Verified
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    SIRT2  
  • Gene symbol
    SIRT2
  • Short name
    SIRT2 Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit IgG
  • Alternative name
    SIRT2 (antibody to-)
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    sirtuin 2
  • Synonyms gene
  • Synonyms gene name
    • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
    • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
  • GenBank acession
  • Locus
  • Discovery year
    1998-10-14
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Sirtuins
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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