SHANK3 Antibody (Center)

• Catalog number
  5317-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  SHANK3
• Target Alternative Name
  SH3 and multiple ankyrin repeat domains 3, ProSAP2, PSAP2, SPANK-2, Proline-rich synapse-associated protein 2
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse
• Immunogen Sequence
  SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.
• Accession
  Q9BYB0
• Gene Id
  85358
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
• Purification
  Affinity chromatography purified via peptide column
• Application
  Western blot, IHC, ELISA
• Positive Control
  Western Blot:3T3 cell Lysate IHC: Human brain tissue
• Application And Usages
  Western Blot: 1 μg/ml, IHC: 2.5 μg/ml, ELISA. However, the optimal conditions should be determined individually.
• Description
  SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SHANK3   Center  
• Gene symbol
  SHANK3
• Short name
  SHANK3 Antibody (Center)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG1
• Alternative name
  SHANK3 (antibody to-) (central)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:14294
• Gene
  SHANK3
• Long gene name
  SH3 and multiple ankyrin repeat domains 3
• Synonyms
  • SPANK-2
  • prosap2
  • KIAA1650
  • PSAP2
• Synonyms name
  • proline rich synapse associated protein 2
  • shank3 postsynaptic density protein
• GenBank acession
  • AB051437
• Locus
  22q13.33
• Discovery year
  2002-02-22
• Entrez gene record
  85358
• Pubmed identfication
  • 11258795
  • 11431708
  • 10806096
  • 17173049
• RefSeq identity
  • NM_001080420
• Classification
  • PDZ domain containing
  • Sterile alpha motif domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000150169

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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