anti-SDHD Antibody

• Catalog number
  6847
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
• Gene names
  SDHD Antibody: TRAP1, TRAP-1, SDH4, CII-4, CybS
• Antibodie s label
  unlabelled serum
• Purity
  SDHD Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  At least three isoforms of THBS are known to exist; this antibody will detect all three.
• Antigen
  SDHD antibody was made against a 15 amino acid synthetic peptide near the center of human SDHD.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
• Antibody advice
  SDHD antibody can be used for detection of SDHD by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 ug/mL. For immunofluorescence start at 2.5 ug/mL.
• Suspention pH azide
  SDHD Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  SDHD antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  4506865
• Ncbi nr
  NP_002993
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  9392
• GENE symbol
  SDHD
• Antigene name
  succinate dehydrogenase complex, subunit D, integral membrane protein
• Source
  Homo sapiens
• Protein nr
  O14521
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SDHD  
• Gene symbol
  SDHD
• Short name
  anti-SDHD Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toSDHD (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10683
• Gene
  SDHD
• Long gene name
  succinate dehydrogenase complex subunit D
• Synonyms gene
  • PGL
  • PGL1
• Synonyms gene name
  • succinate dehydrogenase complex, subunit D, integral membrane protein
• Synonyms
  • cybS
• Synonyms name
  • small subunit of cytochrome b
• GenBank acession
  • AB006202
• Locus
  11q23.1
• Discovery year
  1997-10-21
• Entrez gene record
  6392
• Pubmed identfication
  • 9533030
  • 1301144
• RefSeq identity
  • NM_003002
• Classification
  • Mitochondrial complex II: succinate dehydrogenase subunits
• VEGA ID
  OTTHUMG00000166997
• Locus Specific Databases
  • SDHD @ LOVD
  • Global Variome shared LOVD
  • LRG_9

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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