anti-RNF168 Antibody

• Catalog number
  5147
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  RNF168 Antibody: RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.
• Gene names
  RNF168 Antibody: hRNF168, E3 ubiquitin-protein ligase RNF168, RING finger protein 168, hRNF168
• Antibodie s label
  unlabelled serum
• Purity
  RNF168 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  RNF168 antibody was made against an 18 amino acid synthetic peptide from near the carboxy terminus of human RNF168.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  RNF168 antibody can be used for detection of RNF168 by Western blot at 1 ug/mL.
• Suspention pH azide
  RNF168 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  RNF168 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse
• Omim nr
  31377566
• Ncbi nr
  NP_689830
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  165918
• GENE symbol
  RNF168
• Antigene name
  ring finger protein 168
• Source
  Homo sapiens
• Protein nr
  Q8IYW5
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RNF168  
• Gene symbol
  RNF168
• Short name
  anti-RNF168 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toRNF168 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:26661
• Gene
  RNF168
• Long gene name
  ring finger protein 168
• Synonyms gene name
  • ring finger protein 168, E3 ubiquitin protein ligase
• Synonyms
  • FLJ35794
• GenBank acession
  • AK054732
• Locus
  3q29
• Discovery year
  2005-01-25
• Entrez gene record
  165918
• Pubmed identfication
  • 19203579
  • 29403037
• RefSeq identity
  • NM_152617
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000155582
• Locus Specific Databases
  • LRG_185

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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