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Form
liquid
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Purification
Immunogen affinity purified
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Purity
≥95% as determined by SDS-PAGE
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Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
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Immunogen
proteasome (prosome, macropain) 26S subunit, ATPase, 3
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Synonyms
TBP1
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Calculated MW
Refer to figures
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Uniprot ID
P17980
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Specificity
Human, Mouse, Rat
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Tested Application
ELISA, WB, IHC, IF
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Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
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Image1
Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using FNab06879( PSMC3 Antibody) at dilution of 1:50
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Image4
HeLa cells were subjected to SDS PAGE followed by western blot with FNab06879(PSMC3 antibody) at dilution of 1:1000
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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Properties
If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
PSMC3
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Short name
anti- PSMC3 antibody
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Technique
Antibody, anti, antibody to, antibodies against human proteins, antibodies for
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Host
Rabbit
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Isotype
IgG
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Alternative name
antibody to- proteasome (prosome, macropain) 26S subunit, ATPase, 3 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
proteasome (prosome, macropain) 26S subunit, ATPase, 3, TBP1, PSMC3 and IDBG-43355 and ENSG00000165916 and 5702, nucleoside-triphosphatase activity, nuclei, Psmc3 and IDBG-190080 and ENSMUSG00000002102 and 19182, PSMC3 and IDBG-637440 and ENSBTAG00000021744 and 508448
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