anti-PRPF19 Antibody
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Catalog number29-843
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PricePlease ask
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Size100 ug
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Gene infoPRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.
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Gene namesPRPF19, NMP200, PRP19, PSO4, UBOX4, hPSO4, SNEV
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Antibodie s labelunlabelled serum
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PurityAntibody is purified by protein A chromatography method.
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Ab raised inRabbit
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TypePolyclonal
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AntigenAntibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRPF19.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry
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Antibody advicePRPF19 antibody can be used for detection of PRPF19 by ELISA at 1:1562500. PRPF19 antibody can be used for detection of PRPF19 by western blot at 2.5 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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Suspention pH azideAntibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/mL.
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Keep atFor short periods of storage (days) store at 4 grades C. For longer periods of storage, store PRPF19 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
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Works withHuman, Mouse, Rat, Dog, Zebrafish
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Omim nr7657381
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Ncbi nrNP_055317
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KDa55 kDa
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Vial with antibodyLyophilized
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Quantity per ml1 mg/ml
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NCBI GENE nr27339
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GENE symbolPRPF19
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Antigene namepre-mRNA processing factor 19
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SourceHomo sapiens
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Protein nrQ9UMS4
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPRPF19-DT, PRPF19
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Short nameanti-PRPF19 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toPRPF19 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namePRPF19 divergent transcript
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Locus
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Discovery year2021-03-11
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Entrez gene record
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene namepre-mRNA processing factor 19
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Synonyms gene
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Synonyms gene name
- PRP19/PSO4 homolog (S. cerevisiae)
- PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-02-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NineTeen complex
- U-box domain containing
- Spliceosomal C complex
- WD repeat domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
