Anti-presenilin 1 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-0025M-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Mouse (Mus musculus)
• Target Protein Peptide
  presenilin 1
• Specificity
  This antibody reacts specifically with presenilin 1
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human Presenilin-1 CTF subunit
• Gene ID
  5663
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Rat (Rattus norvegicus), Rabbit
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1;PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Three alternative splice variants of PSEN1 have been identified.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  Presenilin-1 CTF subunit; AD 3; AD3; Ad3h; Alzheimer Disease 3; EC 3.4.23.; FAD; Homo Sapiens Clone CC44 Senilin 1; Presenilin 1 Alzheimer disease 3; Presenilin 1; Presenilin-1 CTF12; PS1-CTF12; Presenilin1; Protein S182; PS 1; PS-1; PS1; PSEN 1; PSEN1; PSN 1; PSN1; PSN1_HUMAN; PSNL 1; PSNL1; S182; S182 Protein; Senilin 1; Senilin1.
• Also known as
  presenilin 1 Polyclonal Antibody
• Other name
  Anti-presenilin 1 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  presenilin  
• Gene symbol
  PARL, PSEN1, HM13
• Short name
  Anti-presenilin 1
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  presenilin 1 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:18253
• Gene
  PARL
• Long gene name
  presenilin associated rhomboid like
• Synonyms gene
  • PSARL
• Synonyms gene name
  • presenilin associated, rhomboid-like
• Synonyms
  • PRO2207
  • PSARL1
  • RHBDS1
• Synonyms name
  • rhomboid 7 homolog 1 (Drosophila)
• GenBank acession
  • AF116692
• Locus
  3q27.1
• Discovery year
  2003-09-03
• Entrez gene record
  55486
• RefSeq identity
  • NM_018622
• Classification
  • Rhomboid family

Gene info

• Identity
  HGNC:9508
• Gene
  PSEN1
• Long gene name
  presenilin 1
• Synonyms gene
  • AD3
• Synonyms gene name
  • Alzheimer disease 3
• Synonyms
  • FAD
  • S182
  • PS1
• GenBank acession
  • AJ008005
• Locus
  14q24.2
• Discovery year
  1992-11-05
• Entrez gene record
  5663
• Pubmed identfication
  • 1411576
• RefSeq identity
  • NM_000021
• Classification
  • Peptidase family A22
• VEGA ID
  OTTHUMG00000141279
• Locus Specific Databases
  • Alzheimer Disease & Frontotemporal Dementia Mutation Database
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_224

Gene info

• Identity
  HGNC:16435
• Gene
  HM13
• Long gene name
  histocompatibility minor 13
• Synonyms
  • H13
  • dJ324O17.1
  • SPP
  • PSL3
  • IMP1
  • IMPAS
  • PSENL3
  • SPPL1
• Synonyms name
  • signal peptide peptidase beta
  • presenilin-like protein 3
  • intramembrane protease
  • signal peptide peptidase like 1
• GenBank acession
  • AL110115
• Locus
  20q11.21
• Discovery year
  2001-09-17
• Entrez gene record
  81502
• Pubmed identfication
  • 12077416
  • 14704149
• RefSeq identity
  • NM_178580
• Classification
  • Peptidase family A22
• VEGA ID
  OTTHUMG00000032175
• Locus Specific Databases
  • LRG_1106

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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