Phospho-BRCA1 (Ser1457) Antibody
-
Catalog number
A1719-100
-
Price
Please ask
-
Size
100 µl
-
-
Antibody Target
Breast cancer type 1 susceptibility protein
-
Target Alternative Name
Breast cancer type 1 susceptibility protein, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1, RNF53
-
Antibody Type
Polyclonal
-
Species Reactivities
Human
-
Immunogen Sequence
A synthesized peptide derived from human BRCA1 around the phosphorylation site of Sersine 1457
-
Accession
P38398
-
Gene Id
672
-
Appearance
Colorless liquid
-
Form
Liquid
-
Concentration
1 mg/ml
-
Formulation
In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Purification
Affinity purified
-
Application
Western Blotting, ELISA
-
Application And Usages
WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000
-
Description
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage.
-
Storage Condition
-20°C
-
Shipping Condition
Gel Pack
-
Shelf Life
12 months
-
Usage
For Research Use Only! Not to be used in humans.
-
Handling
The antibody solution should be gently mixed before use.
-
Western Blot Verified
1
-
ELISA Verified
1
-
-
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
-
Gene target
-
Gene symbol
BRCA1, BRCA1P1
-
Short name
Phospho-BRCA1 (Ser1457) Antibody
-
Technique
Antibody, antibodies against human proteins, antibodies for
-
Isotype
IgG
-
Alternative name
phosphorilated-breast cancer 1, early onset (Ser1457) (antibody to-)
-
Alternative technique
antibodies
-
Alternative to gene target
breast cancer 1, early onset, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, BRCA1 and IDBG-52172 and ENSG00000012048 and 672, androgen receptor binding, nuclei, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120
-
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
BRCA1 pseudogene 1
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year
2005-05-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products