Anti-PDZ RHOGEF (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-4203R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  PDZ RHOGEF
• Specificity
  This antibody reacts specifically with PDZ RHOGEF
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Cytoplasm, Membrane bound
• Antigen Source
  KLH conjugated synthetic peptide derived from human PDZ RHOGEF/GTRAP48
• Gene ID
  9826
• Swiss Prot
  O15085
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  GTRAP48; PDZ-RHOGEF; Rho guanine nucleotide exchange factor 11; ARHGEF11; KIAA0380
• Also known as
  PDZ RHOGEF Polyclonal Antibody
• Other name
  Anti-PDZ RHOGEF Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  PDZ   RHOGEF  
• Gene symbol
  ARHGEF11, ARHGEF17, ARHGEF1, RGS3, ARHGEF15, ARHGEF18, RAPGEF6, RAPGEF2, USH1C
• Short name
  Anti-PDZ RHOGEF
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  PDZ RHOGEF Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:14580
• Gene
  ARHGEF11
• Long gene name
  Rho guanine nucleotide exchange factor 11
• Synonyms gene name
  • Rho guanine nucleotide exchange factor (GEF) 11
• Synonyms
  • KIAA0380
  • GTRAP48
  • PDZ-RHOGEF
• GenBank acession
  • AB002378
• Locus
  1q23.1
• Discovery year
  2001-02-08
• Entrez gene record
  9826
• Pubmed identfication
  • 10526156
  • 9205841
• RefSeq identity
  • NM_198236
• Classification
  • PDZ domain containing
  • Dbl family Rho GEFs
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000041292

Gene info

• Identity
  HGNC:21726
• Gene
  ARHGEF17
• Long gene name
  Rho guanine nucleotide exchange factor 17
• Synonyms gene name
  • Rho guanine nucleotide exchange factor (GEF) 17
• Synonyms
  • TEM4
  • KIAA0337
  • p164-RhoGEF
• Synonyms name
  • Rho-specific guanine-nucleotide exchange factor 164 kDa
  • tumor endothelial marker 4
• GenBank acession
  • AF378754
• Locus
  11q13.4
• Discovery year
  2003-09-25
• Entrez gene record
  9828
• Pubmed identfication
  • 11559528
  • 12071859
• RefSeq identity
  • NM_014786
• Classification
  • Dbl family Rho GEFs
• VEGA ID
  OTTHUMG00000167971

Gene info

• Identity
  HGNC:681
• Gene
  ARHGEF1
• Long gene name
  Rho guanine nucleotide exchange factor 1
• Synonyms gene name
  • Rho guanine nucleotide exchange factor (GEF) 1
• Synonyms
  • P115-RHOGEF
  • SUB1.5
  • LBCL2
• GenBank acession
  • U64105
• Locus
  19q13.2
• Discovery year
  2000-03-10
• Entrez gene record
  9138
• Pubmed identfication
  • 8810315
  • 9135076
• RefSeq identity
  • NM_199002
• Classification
  • Dbl family Rho GEFs
• VEGA ID
  OTTHUMG00000182679

Gene info

• Identity
  HGNC:9999
• Gene
  RGS3
• Long gene name
  regulator of G protein signaling 3
• Synonyms gene name
  • regulator of G-protein signalling 3
  • regulator of G-protein signaling 3
• Synonyms
  • C2PA
  • FLJ20370
  • PDZ-RGS3
• GenBank acession
  • AF006610
• Locus
  9q32
• Discovery year
  1997-06-09
• Entrez gene record
  5998
• Pubmed identfication
  • 8602223
  • 11034339
• RefSeq identity
  • NM_017790
• Classification
  • Regulators of G-protein signaling
  • C2 domain containing
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000021048

Gene info

• Identity
  HGNC:15590
• Gene
  ARHGEF15
• Long gene name
  Rho guanine nucleotide exchange factor 15
• Synonyms gene name
  • Rho guanine nucleotide exchange factor (GEF) 15
• Synonyms
  • KIAA0915
  • Vsm-RhoGEF
  • ARGEF15
  • FLJ13791
  • MGC44868
• Synonyms name
  • Rho guanine exchange factor (GEF) 15
  • ephexin5
• GenBank acession
  • AB020722
• Locus
  17p13.1
• Discovery year
  2001-04-26
• Entrez gene record
  22899
• Pubmed identfication
  • 10048485
• RefSeq identity
  • NM_173728
• Classification
  • Dbl family Rho GEFs
• VEGA ID
  OTTHUMG00000108187

Gene info

• Identity
  HGNC:17090
• Gene
  ARHGEF18
• Long gene name
  Rho/Rac guanine nucleotide exchange factor 18
• Synonyms gene name
  • rho/rac guanine nucleotide exchange factor (GEF) 18
  • Rho/Rac guanine nucleotide exchange factor (GEF) 18
• Synonyms
  • P114-RhoGEF
  • KIAA0521
  • MGC15913
  • p114RhoGEF
• Synonyms name
  • Rho-specific guanine nucleotide exchange factor p114
• GenBank acession
  • AK074372
• Locus
  19p13.2
• Discovery year
  2004-01-09
• Entrez gene record
  23370
• Pubmed identfication
  • 9628581
  • 11318610
• RefSeq identity
  • NM_015318
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000177342

Gene info

• Identity
  HGNC:20655
• Gene
  RAPGEF6
• Long gene name
  Rap guanine nucleotide exchange factor 6
• Synonyms gene
  • PDZGEF2
• Synonyms gene name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 2
  • Rap guanine nucleotide exchange factor (GEF) 6
• Synonyms
  • RA-GEF-2
  • PDZ-GEF2
• GenBank acession
  • AF117947
• Locus
  5q31.1
• Discovery year
  2003-09-03
• Entrez gene record
  51735
• Pubmed identfication
  • 11524421
  • 12095257
• RefSeq identity
  • NM_016340
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000162683

Gene info

• Identity
  HGNC:16854
• Gene
  RAPGEF2
• Long gene name
  Rap guanine nucleotide exchange factor 2
• Synonyms gene
  • PDZGEF1
• Synonyms gene name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 1
  • Rap guanine nucleotide exchange factor (GEF) 2
• Synonyms
  • PDZ-GEF1
  • RA-GEF
  • DKFZP586O1422
  • KIAA0313
• Synonyms name
  • Rap GEP
• GenBank acession
  • AB002311
• Locus
  4q32.1
• Discovery year
  2003-05-20
• Entrez gene record
  9693
• Pubmed identfication
  • 9205841
  • 10934204
• RefSeq identity
  • NM_014247
• Classification
  • MicroRNA protein coding host genes
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000161451

Gene info

• Identity
  HGNC:12597
• Gene
  USH1C
• Long gene name
  USH1 protein network component harmonin
• Synonyms gene
  • DFNB18
• Synonyms gene name
  • deafness, autosomal recessive 18
  • Usher syndrome 1C (autosomal recessive, severe)
  • Usher syndrome 1C
• Synonyms
  • PDZ73
  • harmonin
  • NY-CO-37
  • NY-CO-38
  • PDZ-73
  • AIE-75
  • PDZD7C
• Synonyms name
  • harmonin
• GenBank acession
  • AB006955
• Locus
  11p15.1
• Discovery year
  1992-06-08
• Entrez gene record
  10083
• Pubmed identfication
  • 10973247
  • 12107438
• RefSeq identity
  • NM_005709
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000166323
• Locus Specific Databases
  • Mutations of the Harmonin Gene
  • CCHMC-BMI & UC Hearing Loss Mutation Database

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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