anti-PATZ1 Antibody
-
Catalog number25-473
-
PricePlease ask
-
Size50 ug
-
-
Gene infoPATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1;22) (p36.1;q12).The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1;22) (p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
-
Gene namesPATZ1, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
-
Antibodie s labelunlabelled serum
-
PurityAntibody is purified by peptide affinity chromatography method.
-
Ab raised inRabbit
-
TypePolyclonal
-
AntigenAntibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PATZ1.
-
Immuno applicationELISA, Western Blot
-
Antibody advicePATZ1 antibody can be used for detection of PATZ1 by ELISA at 1:1562500. PATZ1 antibody can be used for detection of PATZ1 by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
-
Suspention pH azideAntibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
-
Keep atFor short periods of storage (days) store at 4 grades C. For longer periods of storage, store PATZ1 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
-
Works withHuman, Mouse, Rat
-
Omim nr14670360
-
Ncbi nrNP_055138
-
KDa74 kDa
-
Vial with antibodyLyophilized
-
Quantity per ml1 mg/ml
-
NCBI GENE nr23598
-
GENE symbolPATZ1
-
Antigene namePOZ (BTB) and AT hook containing zinc finger 1
-
SourceHomo sapiens
-
Protein nrQ9HBE1
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolPATZ1
-
Short nameanti-PATZ1 Antibody
-
TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
Alternative nameAntibody toPATZ1 (antibody to-)
-
Alternative techniqueantibodies
-
Alternative to gene targetPOZ (BTB) and AT hook containing zinc finger 1, dJ400N23 and MAZR and PATZ and RIAZ and ZBTB19 and ZNF278 and ZSG, PATZ1 and IDBG-4572 and ENSG00000100105 and 23598, metal ion binding, nuclei, Patz1 and IDBG-138937 and ENSMUSG00000020453 and 56218, PATZ1 and IDBG-636698 and ENSBTAG00000005478 and 532416
-
Gene info
-
Identity
-
Gene
-
Long gene namePOZ/BTB and AT hook containing zinc finger 1
-
Synonyms gene
-
Synonyms gene name
- zinc finger protein 278
- POZ (BTB) and AT hook containing zinc finger 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-10-20
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- BTB domain containing
- Zinc fingers C2H2-type
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data