PARP Antibody
-
Catalog numberPB9309
-
PricePlease ask
-
Size0,1 mg
-
-
Target antigenPARP
-
ClonalityPolyclonal antibody
-
ClonePolyclonal antibody
-
Raised inrabbit
-
Type of the antibodyIgG polyclonal antibody
-
Product formfreeze-dried
-
Reacts with speciesrat Theoretical reactivity:human
-
AnalysesWB,IHC-P,ICC
-
ImmunogenE.coli-derived human PARP recombinant protein (Position: Q670-R858). Human PARP shares 94% and 95% amino acid (aa) sequence identity with mouse and rat PARP, respectively.
-
Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
-
PurificationImmunogen affinity purified.
-
SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
-
Storage condtionsKeep the PARP Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
-
TipsThe PARP Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
-
BackgroundPoly [ADP-ribose] polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
-
Related articles1. Ambrose, H. E., Willimott, S., Beswick, R. W., Dantzer, F., Menissier de Murcia, J., Yelamos, J., Wagner, S. D. Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses. Immunology 127: 178-186, 2008. 2. Doege, C. A., Inoue, K., Yamashita, T., Rhee, D. B., Travis, S., Fujita, R., Guarnieri, P., Bhagat, G., Vanti, W. B., Shih, A., Levine, R. L., Nik, S., Chen, E. I., Abeliovich, A. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 488: 652-655, 2012.
-
Gene NamePARP1
-
Protein NamePoly [ADP-ribose] polymerase 1
-
Gene Full Namepoly (ADP-ribose) polymerase 1
-
SynonymsADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody|ADP ribosyltransferase diphtheria toxin like 1 antibody|ADP ribosyltransferase NAD(+) antibody|ADP ribosyltransferase NAD+ antibody|ADPRT 1 antibody|ADPRT antibody|ADPRT1 antibody|ARTD1 antibody|msPARP antibody|NAD(+) ADP ribosyltransferase 1 antibody|NAD(+) ADP-ribosyltransferase 1 antibody|pADPRT 1 antibody|pADPRT1 antibody|PARP 1 antibody|PARP antibody|PARP-1 antibody|PARP1 antibody|PARP1_HUMAN antibody|Poly (ADP ribose) polymerase 1 antibody|poly (ADP ribose) polymerase family, member 1 antibody|Poly [ADP-ribose]polymerase 1 antibody|Poly adenosine diphosphate ADP ribose polymerase antibody|Poly ADP ribose polymerase 1 antibody|Poly ADP ribose polymerase family member 1 antibody|Poly ADP ribose synthetase 1 antibody|Poly(ADP ribose) polymerase antibody|poly(ADP ribose) synthetase antibody|poly(ADP ribosyl)transferase antibody|Poly[ADP ribose] synthetase 1 antibody|Poly[ADP-ribose] synthase 1 antibody|PPOL antibody
-
Uniprot IDP09874
-
Entrez GeneID142
-
PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolTNKS2, TIPARP, PARP1, PARP12, TNKS
-
Short namePARP Antibody
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
Alternative namePARP (antibody to-)
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene nametankyrase 2
-
Synonyms gene name
- tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-05-10
-
Entrez gene record
-
RefSeq identity
-
Classification
- Poly(ADP-ribose) polymerases
- Sterile alpha motif domain containing
- Ankyrin repeat domain containing
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameTCDD inducible poly(ADP-ribose) polymerase
-
Synonyms gene name
- TCDD-inducible poly(ADP-ribose) polymerase
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-12-02
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Poly(ADP-ribose) polymerases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namepoly(ADP-ribose) polymerase 1
-
Synonyms gene
-
Synonyms gene name
- ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
- poly (ADP-ribose) polymerase family, member 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1986-01-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Zinc fingers PARP-type
- Zinc fingers
- Poly(ADP-ribose) polymerases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namepoly(ADP-ribose) polymerase family member 12
-
Synonyms gene
-
Synonyms gene name
- zinc finger CCCH-type domain containing 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-12-10
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Poly(ADP-ribose) polymerases
- Zinc fingers CCCH-type
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nametankyrase
-
Synonyms gene name
- tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1999-01-08
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Poly(ADP-ribose) polymerases
- Sterile alpha motif domain containing
- Ankyrin repeat domain containing
- MicroRNA protein coding host genes
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data