p95 NBS1 (Ser343) Antibody, ALEXA FLUOR 594

• Catalog number
  bs-3718R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  p95 NBS1 (Ser343) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-p95 NBS1 Ser343 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  p95 NBS1 Ser343
• Specificity
  This is a highly specific antibody against p95 NBS1 Ser343.
• Modification
  Phosphorylation
• Modification Site
  Ser343
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  320-370/754
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human NBS1 around the phosphorylation site of Ser343
• Gene ID Number
  4683
• Swiss Prot
  O60934
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  ATV; NBS; P95; NBS1; AT-V1; AT-V2; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1; NBN
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  p95   NBS1   Ser343  
• Gene symbol
  NLRP2, NBN
• Short name
  Anti-p95 NBS1 Ser343
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  p95 NBS1 (Ser343) Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:22948
• Gene
  NLRP2
• Long gene name
  NLR family pyrin domain containing 2
• Synonyms gene
  • NALP2
• Synonyms gene name
  • NACHT, leucine rich repeat and PYD containing 2
• Synonyms
  • FLJ20510
  • PYPAF2
  • NBS1
  • PAN1
  • CLR19.9
• Synonyms name
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
• GenBank acession
  • AK000517
• Locus
  19q13.42
• Discovery year
  2003-10-28
• Entrez gene record
  55655
• Pubmed identfication
  • 12563287
  • 11270363
• RefSeq identity
  • NM_017852
• Classification
  • Pyrin domain containing
  • NLR family
• VEGA ID
  OTTHUMG00000167763

Gene info

• Identity
  HGNC:7652
• Gene
  NBN
• Long gene name
  nibrin
• Synonyms gene
  • NBS
  • NBS1
• Synonyms gene name
  • Nijmegen breakage syndrome 1 (nibrin)
• Synonyms
  • ATV
  • AT-V2
  • AT-V1
• GenBank acession
  • AF058696
• Locus
  8q21.3
• Discovery year
  1997-11-28
• Entrez gene record
  4683
• Pubmed identfication
  • 9590181
  • 9590180
• RefSeq identity
  • NM_001024688
• Classification
  • MRN complex
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000153546
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_158

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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