P-glycoprotein Antibody

• Catalog number
  6970-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  P-glycoprotein
• Target Alternative Name
  P-gp, Multidrug resistance protein 1, MDR1, ATP-binding cassette sub-family B (MDR/TAP) member 1, ABCB1
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  Synthetic peptide corresponding to amino acids around position 630 of human P-glycoprotein
• Accession
  P08183
• Gene Id
  5243
• Appearance
  Solid
• Form
  Lyophilized
• Formulation
  Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3
• Purification
  Immunogen affinity purified antibody
• Application
  IHC-P, IHC-F
• Positive Control
  IHC: Mouse Kidney, Mouse Intestine, Rat Kidney, Human Lung Cancer tissue
• Application And Usages
  IHC: 1:500-1:1000 of 0.5 mg/ml stock
• Description
  P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The vial should be centrifuged to collect the lyophilized solid before reconstituting
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  P-glycoprotein  
• Gene symbol
  APCS, ABCB5, ALG3
• Short name
  P-glycoprotein Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  P-glycoprotein (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:584
• Gene
  APCS
• Long gene name
  amyloid P component, serum
• Synonyms
  • SAP
  • PTX2
  • MGC88159
• Synonyms name
  • pentraxin-related
  • 9.5S alpha-1-glycoprotein
  • pentraxin-2
• Locus
  1q23.2
• Discovery year
  2001-06-22
• Entrez gene record
  325
• Pubmed identfication
  • 2987268
• RefSeq identity
  • NM_001639
• Classification
  • Short pentraxins
• VEGA ID
  OTTHUMG00000022741

Gene info

• Identity
  HGNC:46
• Gene
  ABCB5
• Long gene name
  ATP binding cassette subfamily B member 5
• Synonyms gene name
  • ATP-binding cassette, sub-family B (MDR/TAP), member 5
• Synonyms
  • EST422562
  • ABCB5beta
  • ABCB5alpha
• Synonyms name
  • P-glycoprotein ABCB5
  • ATP-binding cassette protein
• GenBank acession
  • U66692
• Locus
  7p21.1
• Discovery year
  1999-10-26
• Entrez gene record
  340273
• Pubmed identfication
  • 8894702
  • 12960149
• RefSeq identity
  • NM_178559
• Classification
  • ATP binding cassette subfamily B
• VEGA ID
  OTTHUMG00000094789

Gene info

• Identity
  HGNC:23056
• Gene
  ALG3
• Long gene name
  ALG3 alpha-1,3- mannosyltransferase
• Synonyms gene name
  • asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)
  • asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)
• Synonyms
  • NOT56L
  • Not56
  • CDGS4
  • D16Ertd36e
• Synonyms name
  • carbohydrate deficient glycoprotein syndrome type IV
  • dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
  • dol-P-Man dependent alpha-1,3- mannosyltransferase
• GenBank acession
  • BC002839
• Locus
  3q27.1
• Discovery year
  2003-10-15
• Entrez gene record
  10195
• Pubmed identfication
  • 1058125
• RefSeq identity
  • NM_005787
• Classification
  • Dolichyl D-mannosyl phosphate dependent mannosyltransferases
• VEGA ID
  OTTHUMG00000156823
• Locus Specific Databases
  • Congenital Disorder of Glycosylation pages

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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