anti-NAK Antibody

• Catalog number
  2351
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  NAK Antibody: Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. Phosphorylation of I-kappaB by IkB kinase (IKK) complex leads to degradation of I-kappaB and activation of NF-kB. The IKK complex contains IKKa;, IKKβ, and IKKγ. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-kB-activating kinase), and T2K. NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
• Gene names
  NAK Antibody: NAK, T2K, NAK, NF-kappa-B-activating kinase
• Antibodie s label
  unlabelled serum
• Purity
  NAK Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  No cross response to IKKa, IKKb, IKKy, or IKKe.
• Antigen
  NAK antibody was made against a synthetic peptide corresponding to 17 amino acids form near the carboxy terminus of human NAK/TBK1.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry
• Antibody advice
  NAK antibody can be used for detection of NAK/TBK1 by Western blot. An 84 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 10 ug/mL.
• Suspention pH azide
  NAK Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  NAK antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse
• Omim nr
  7019547
• Ncbi nr
  NP_037386
• KDa
  84 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  29110
• GENE symbol
  TBK1
• Antigene name
  TANK-binding kinase 1
• Source
  Homo sapiens
• Protein nr
  Q9UHD2
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NAK  
• Gene symbol
  TBK1, NR4A1
• Short name
  anti-NAK Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toNAK (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11584
• Gene
  TBK1
• Long gene name
  TANK binding kinase 1
• Synonyms gene name
  • TANK-binding kinase 1
• Synonyms
  • NAK
• GenBank acession
  • AF191838
• Locus
  12q14.2
• Discovery year
  2000-06-08
• Entrez gene record
  29110
• Pubmed identfication
  • 10581243
  • 10783893
• RefSeq identity
  • NM_013254
• Classification
  • I kappa B kinases
• VEGA ID
  OTTHUMG00000168796
• Locus Specific Databases
  • LRG_1306

Gene info

• Identity
  HGNC:7980
• Gene
  NR4A1
• Long gene name
  nuclear receptor subfamily 4 group A member 1
• Synonyms gene
  • HMR
  • GFRP1
• Synonyms gene name
  • nuclear receptor subfamily 4, group A, member 1
• Synonyms
  • TR3
  • N10
  • NAK-1
  • NGFIB
  • NUR77
• GenBank acession
  • L13740
• Locus
  12q13.13
• Discovery year
  1990-09-10
• Entrez gene record
  3164
• Pubmed identfication
  • 2626032
• Classification
  • Nuclear receptor subfamily 4 group A
• VEGA ID
  OTTHUMG00000150393

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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