anti-Norrin Antibody

• Catalog number
  5119
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Norrin Antibody: Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
• Gene names
  Norrin Antibody: ND, EVR2, FEVR, Norrin, Norrie disease protein
• Antibodie s label
  unlabelled serum
• Purity
  Norrin Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  Norrin antibody was made against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry
• Antibody advice
  Norrin antibody can be used for detection of Norrin by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 5 ug/mL.
• Suspention pH azide
  Norrin Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Norrin antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  4557789
• Ncbi nr
  NP_000257
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  4693
• GENE symbol
  NDP
• Antigene name
  Norrie disease (pseudoglioma)
• Source
  Homo sapiens
• Protein nr
  Q00604
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Norrin  
• Gene symbol
  NDP
• Short name
  anti-Norrin Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toNorrin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7678
• Gene
  NDP
• Long gene name
  norrin cystine knot growth factor NDP
• Synonyms gene
  • EVR2
• Synonyms gene name
  • exudative vitreoretinopathy 2 (X-linked)
  • Norrie disease (pseudoglioma)
• Synonyms
  • norrin
• GenBank acession
  • X65882
• Locus
  Xp11.3
• Discovery year
  2001-06-22
• Entrez gene record
  4693
• Pubmed identfication
  • 8252044
• RefSeq identity
  • NM_000266
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000021391
• Locus Specific Databases
  • Mutations of the Norrie Disease Gene

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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