Noggin Antibody

• Catalog number
  5775-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  Noggin
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  E. coli expressed recombinant human Noggin
• Accession
  AAA83259.1
• Gene Id
  1117817
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Recombinant human Noggin (Cat.# 4675-20) can be used as a positive control.
• Description
  Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Noggin  
• Gene symbol
  NOG
• Short name
  Noggin Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Noggin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7866
• Gene
  NOG
• Long gene name
  noggin
• Synonyms gene
  • SYNS1
  • SYM1
• Synonyms gene name
  • synostoses (multiple) syndrome 1
  • symphalangism 1 (proximal)
• GenBank acession
  • U31202
• Locus
  17q22
• Discovery year
  1999-03-24
• Entrez gene record
  9241
• Pubmed identfication
  • 7666191
  • 10080184
  • 11545688
• RefSeq identity
  • NM_005450
• VEGA ID
  OTTHUMG00000151770

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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