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Gene info
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s disease, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NR1 subunit of the receptor has been associated with synaptic plasticity. There are a number of different splice variants of the NR1. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR.
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Gene names
NR1, GluN1, NMDAR1, Nmdar1, N-methyl-D-aspartate receptor subunit NR1,
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Antibodie s label
unlabelled serum
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Purity
Affinity Purified
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Ab raised in
Rabbit
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Type
Polyclonal
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Antigen
NMDA NR1, Splice Variant C2 polyclonal antibody was made against a peptide containing the C2 insert.
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Immuno application
Western Blot, immuno-histo-chemistry
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Antibody advice
NMDA NR1, Splice Variant C2 antibody allows for strong and specific immunolabeling of the NR1 subunit containing the C2 splice variant insert. Does not recognize NR1 subunits that do not contain the C2 insert. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-NMDA NR1, Splice Variant C2 recognizes NR1 in rat and mouse brain. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.
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Keep at
NMDA NR1, Splice Variant C2 antibody can be stored at -20 grades C. After reconstitution in 50 μl PBS, the antibody should be aliquot and stored at -20 grades C and is stable at -20 grades C for at least 1 year. Ambient shipment is suitable for both international and domestic.
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Works with
Rat
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Omim nr
548379
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Ncbi nr
P35439
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KDa
120
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Vial with antibody
Lyophilized
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NCBI GENE nr
24408
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GENE symbol
Grin1
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Antigene name
glutamate receptor, ionotropic, N-methyl D-aspartate 1
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Source
Rattus norvegicus
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Protein nr
P35439
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
