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Gene info
NFkB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFkB1) subunits. Other identified subunits include p52 (NFkB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.
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Gene names
NFKBIB, IKBB, I-kappa-B-beta, IkappaBbeta, NF-kappa-B inhibitor beta, IkB-beta, TRIP9, TRIP-9, IkB-B, NF-kappa-BIB, TR-interacting protein 9
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Antibodie s label
unlabelled serum
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Purity
Delipidation and Defibrination
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Ab raised in
Rabbit
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Type
Polyclonal
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Antigen
NFKBIB antibody was made against amino acids 1 - 19 of NFKBIB (Human).
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence, immuno precipitation
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Antibody advice
NFKBIB antibody can be used in immunohistochemistry starting at 10 ug/mL.
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Keep at
Store NFKBIB antibody at -20 grades C or below prior to opening. Dilute only prior to immediate use. Aliquot contents and freeze at -20 grades C or below. As with all antibodies avoid freeze/thaw cycles.
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Works with
Human, Mouse, Rat
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Omim nr
57015399
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Ncbi nr
Q15653
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Vial with antibody
in solution
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NCBI GENE nr
4793
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GENE symbol
NFKBIB
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Antigene name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
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Source
Homo sapiens
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Protein nr
Q15653
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
NFKBIB
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Short name
anti-NFKBIB Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody tonuclear factor on kappa light polypeptide gene enhancer in B-cells inhibitor, b (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta, IKBB and TRIP9, NFKBIB and IDBG-49787 and ENSG00000104825 and 4793, protein binding, nuclei, Nfkbib and IDBG-164189 and ENSMUSG00000030595 and 18036, NFKBIB and IDBG-637425 and ENSBTAG00000001778 and 525408
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