anti-Myeloperoxidase Antibody

• Catalog number
  49-451
• Price
  Please ask
• Size
  0.05 mL

• Gene info
  Human myeloperoxidase (MPO) is a dimeric protein composed of two heavy subunits (53 kDa) and two light subunits (15 kDa). Each MPO molecule contains two prosthetic porphyrins which play an important role in the catalytic cycle. Molecular weights for MPO isoforms from pools of normal human samples range from 114,000 to 140,000 daltons reflecting a heterogeneous mixture of isoforms when assayed under non-reducing conditions of SDS-PAGE. Often MPO from a single donor will yield a homogenous preparation reflecting a single isoform. The carbohydrate component of MPO, consisting of mannose, glucose and N-acetylglucosamine residues is 2.5%. MPO is inhibited by azide and other compounds. MPO is stored in primary granules of neutrophils and serves as a bactericidal agent in that MPO catalyzes the production of hypochlorous acid (HOCl), a powerful oxidant. HOCl is derived from chloride ion (Cl-) and hydrogen peroxide (H2O2). In a number of inflammatory situations, MPO is released into the extracellular matrix where its measurement can be used as an indication of neutrophil activation.
• Gene names
  MPO, Myeloperoxidase precursor, Myeloperoxidase
• Antibodie s label
  unlabelled serum
• Purity
  Delipidation and Defibrination
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Myeloperoxidase antibody was made against amino acids 3 - 14 of Myeloperoxidase (Human).
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence, immuno precipitation
• Antibody advice
  Myeloperoxidase antibody can be used in immunohistochemistry starting at 10 ug/mL.
• Suspention pH azide
  PBS, pH 7.2, 0.01% sodium azide.
• Keep at
  Store Myeloperoxidase antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  129825
• Ncbi nr
  P05164
• Vial with antibody
  in solution
• NCBI GENE nr
  4353
• GENE symbol
  MPO
• Antigene name
  myeloperoxidase
• Source
  Homo sapiens
• Protein nr
  P05164
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Myeloperoxidase  
• Gene symbol
  MPO
• Short name
  anti-Myeloperoxidase Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toMyeloperoxidase (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7218
• Gene
  MPO
• Long gene name
  myeloperoxidase
• Locus
  17q22
• Discovery year
  2001-06-22
• Entrez gene record
  4353
• VEGA ID
  OTTHUMG00000178922
• Locus Specific Databases
  • MPObase: Mutation registry for Myeloperoxidase deficiency
  • LRG_84

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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