Anti-MUNC-18 (pSer515)
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Catalog numberMBS221521
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PricePlease ask
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Size100ul
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Alternative name1Anti-RABBIT ANTI MUNC-18 (pSer515)
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Alternative name2RABBIT ANTI MUNC-18 (pSer515)
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Alternative name3Lapin ANTI MUNC-18 (pSer515)
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Alternative name4MUNC-18
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Alternative name5N/A
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Other namessyntaxin-binding protein 1; Syntaxin-binding protein 1; syntaxin-binding protein 1; p67; unc-18A; unc-18-1; unc-18 homolog; protein unc-18 homolog 1; protein unc-18 homolog A; syntaxin binding protein 1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67; rbSec1
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Gene nameMUNC-18
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Gene name synonimsN/A
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Other gene namesStxbp1; Stxbp1; Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1; Unc18a; Unc18-1; Unc-18A
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CategoryAntibodies
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ClonalityPolyclonal
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Immunoglobulin isotypePolyclonal IgG
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ClonePolyclonal antibody
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Host organismRabbit
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Species reactivityRat
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Specificity and cross reactivityMUNC-18 This item recognises Munc-18 phosphorylated at serine 515, a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. _x000D__x000D_Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.
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Purification methodN/A
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Form AppearancePurified (Purified IgG - liquid)
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ConcentrationN/A
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Storage and shippingStore at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of dispatch.
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Tested forWestern Blot (WB)
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Descriptionproductone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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AdvisoryIn order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Gene target
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Gene symbolSNORD114-18, PIRC96, SNORD116-18, IGLV2-18, IGHV1-18, SNORD115-18, ERVW-18, IGKV2D-18, IGKV2-18
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Short nameAnti-MUNC-18 (pSer515)
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Techniqueanti-, anti, antibody to, antibodies
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Alternative nameAntibody toMUNC-18 (pSer515)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 114-18
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Synonyms
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Locus
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Discovery year2006-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 96
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 116-18
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable 2-18
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 1-18
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-18
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameendogenous retrovirus group W member 18
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Synonyms gene name
- endogenous retrovirus group W, member 18
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GenBank acession
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Locus
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Discovery year2013-10-21
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2D-18 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 2D-18
- immunoglobulin kappa variable 2D-18 pseudogene
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa locus at 2p11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2-18 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 2-18
- immunoglobulin kappa variable 2-18 pseudogene
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa locus at 2p11.2
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
