MRP4 Antibody

• Catalog number
  A01596
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  MRP4
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human
• Analyses
  WB
• Immunogen
  E.coli-derived human MRP4 recombinant protein (Position: M1-K77).
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the MRP4 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The MRP4 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  ABCC4(Atp-binding cassette, subfamily c, member 4), also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
• Related articles
  1. Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., van Eijk, M. J., Juijn, J. A., Baas, F., Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57: 3537-3547, 1997. 2. Lee, K., Belinsky, M. G., Bell, D. W., Testa, J. R., Kruh, G. D. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Res. 58: 2741-2747, 1998. 3. van de Ven, R., Scheffer, G. L., Reurs, A. W., Lindenberg, J. J., Oerlemans, R., Jansen, G., Gillet, J.-P., Glasgow, J. N., Pereboev, A., Curiel, D. T., Scheper, R. J., de Gruijl, T. D. A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration.Blood 112: 2353-2359, 2008.
• Gene Name
  ABCC4
• Protein Name
  Multidrug resistance-associated protein 4
• Gene Full Name
  ATP-binding cassette, sub-family C (CFTR/MRP), member 4
• Synonyms
  ABCC4 | MOATB | MOAT-B | MRP4 | O15439
• Uniprot ID
  O15439
• Entrez GeneID
  10257
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MRP4  
• Gene symbol
  ABCC4
• Short name
  MRP4 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  MRP4 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:55
• Gene
  ABCC4
• Long gene name
  ATP binding cassette subfamily C member 4
• Synonyms gene name
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4
• Synonyms
  • MRP4
  • EST170205
  • MOAT-B
  • MOATB
• Synonyms name
  • canalicular multispecific organic anion transporter (ABC superfamily)
  • bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
  • multidrug resistance-associated protein 4
  • multispecific organic anion transporter B
• GenBank acession
  • U66682
• Locus
  13q32.1
• Discovery year
  1999-10-26
• Entrez gene record
  10257
• Pubmed identfication
  • 8894702
  • 9661885
• RefSeq identity
  • NM_005845
• Classification
  • ATP binding cassette subfamily C
• VEGA ID
  OTTHUMG00000017216
• Locus Specific Databases
  • LRG_1183

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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