Anti Mouse Dectin
Anti Mouse Dectin is available 2 times from Reliatech antibodies labs
- Species ReactivityMouse (Mus musculus)
- DescriptionThis is a highly purified antibody with strong binding affinity towards the antigen that it has been risen against.Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in.
- Storage and handlingLyophilized antibodies can be shipped at ambient temperature and stored for short terms at +4 degrees Celsius and at -20 for long term storage. Reconstituted lyophilised and antibodies in liquid form can be shipped and stored for short terms at +4 degrees Celsius. Generally, it is recomended for long term storage (up to one year) 25-50% glycerol or ethylene glycol to be added and the vial must be stored at -20°C.
- AdvisoryIn order to retain the quality and the affinity of the antibodies unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
- Additional descriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
- TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
- Latin nameMus musculus
- TechniqueMouse, anti
- Alternative techniqueantibodies
103-M370 | Anti-Mouse Dectin-1size: 100ug | 413.31 USD
103-M371 | Anti-Mouse Dectin-2size: 100ug | 413.31 USD
- Catalog number103-M371
- Price413.31 USD
1. Gene info
- Long gene nameC-type lectin domain containing 6A
- Synonyms gene
- Synonyms gene name
- C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
- C-type lectin domain family 6, member A
- C-type lectin domain family 6 member A
- GenBank acession
- Discovery year2004-11-18
- Entrez gene record
- RefSeq identity
- C-type lectin domain containing
- Havana BLAST/BLAT
- ConceptScope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
- Tree numbers
- Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
- PubMedModulation of dectin-1 receptor levels correlates with the ability of activated macrophages to bind zymosan and significantly affects the contribution of the receptor to the resultant proinflammatory response, as measured by the production of TNF-alpha.required for Pneumocystis carinii-induced macrophage inflammatory protein 2 production by alveolar macrophagesThis report provides evidence that arachidonate release in macrophages by zymozan is mediated by beta-glucan receptor dectin 1.findings show that the gut contains a fungal community that interacts with the immune system through the innate immune receptor Dectin-1; mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungiDectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.In both cases, these beta-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.In conclusion, dectin-1 exerts an important protective role in pulmonary paracoccidioidomycosis by controlling the innate and adaptive phases of antifungal immunity.the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to natural killer-mediated killing of tumor cells that express N-glycan structures at high levels.
- Entrez Gene