anti-Mcl-1 Antibody

• Catalog number
  3481
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  Mcl-1 Antibody: Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
• Gene names
  Mcl-1 Antibody: TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3
• Antibodie s label
  unlabelled serum
• Purity
  Mcl-1 Antibody is Ion exchange chromatography purified.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Spicific to
  Detects isoforms Mcl-1L and Mcl-1S
• Antigen
  Mcl-1 antibody was made against a peptide corresponding to 16 amino acids near the center of human Mcl-1.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry
• Antibody advice
  Mcl-1 antibody can be used for detection of isoforms Mcl-1L and Mcl-1S by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 10 ug/mL.
• Suspention pH azide
  Mcl-1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  Mcl-1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  11386165
• Ncbi nr
  NP_068779
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  4170
• GENE symbol
  MCL1
• Antigene name
  myeloid cell leukemia sequence 1 (BCL2-related)
• Source
  Homo sapiens
• Protein nr
  Q07820
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Mcl-1  
• Gene symbol
  MCL1
• Short name
  anti-Mcl-1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toMcl-1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6943
• Gene
  MCL1
• Long gene name
  MCL1 apoptosis regulator, BCL2 family member
• Synonyms gene name
  • myeloid cell leukemia sequence 1 (BCL2-related)
  • myeloid cell leukemia 1
  • MCL1, BCL2 family apoptosis regulator
• Synonyms
  • BCL2L3
  • Mcl-1
• GenBank acession
  • BC017197
• Locus
  1q21.2
• Discovery year
  1993-11-09
• Entrez gene record
  4170
• Pubmed identfication
  • 7682708
  • 7835896
• RefSeq identity
  • NM_021960
• Classification
  • BCL2 family
• VEGA ID
  OTTHUMG00000034867

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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