anti-LC3 (APG8C) Antibody

anti-LC3 (APG8C) Antibody is available 1 time from Biovision labs

6950-100 | anti-LC3 (APG8C) Antibodysize: LC3 (APG8C) Antibody | 410.08 USD

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  • Target of this antibody:
    LC3
  • Alternative names of antibody target:
    MAP1LC3C; Microtubule-associated proteins 1A/1B light chain 3C; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; Microtubule-associated protein 1 light chain 3 gamma
  • Background information:
    Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.
  • Antibody host:
    Rabbit
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit Ig
  • This antibody reacts with:
    Human.
  • Immunogene sequence:
    This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LC3.
  • Concentration of antibody:
    N/A
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    Supplied in PBS with 0.09% (W/V) sodium azide.
  • Purification method:
    Ammonium sulphate precipitated and dialyzed Antibody
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunohistochemistry
  • Recommended usage:
    WB: ~1:1000, IHC: 1:50-100.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-LC3 (APG8C) Antibody
  • Technique
    Antibody, anti
  • Alternative name
    antibody to-LC3 (APG8C) (Antibody to)
  • Alternative technique
    antibodies
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