anti-Caspase-12 Antibody (Large)
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Catalog number
3195
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Price
Please ask
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Size
0.02 mg, 0.1 mg
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Gene info
Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
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Gene names
Caspase-12 (Large) Antibody: Caspase-12, CASP-12
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Antibodie s label
unlabelled serum
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Purity
Caspase-12 (Large) Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
This is a polyclonal Caspase-12 Antibody.
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Immunoglobulin
IgG
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Spicific to
Caspase-12 (large) antibody is predicted to have no cross reactivity to other members in the caspase family.
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Antigen
Caspase-12 antibody was made against a synthetic peptide corresponding to 16 amino acids within the large cleavage product of murine caspase-12.
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
Caspase-12 (large) antibody can be used for the detection of both the propeptide and cleaved forms of caspase-12 by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
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Suspention pH azide
Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Large)
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Keep at
Caspase-12 (Large) antibody can be stored at -20 grades C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human, Mouse, Rat
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Omim nr
2094806
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Ncbi nr
CAA73532
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KDa
Predicted: 46 kDa Observed: 46 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
12364
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GENE symbol
Casp12
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Antigene name
caspase 12
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Source
Mus musculus
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Protein nr
O08736
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
CASP12, AVEN, NLRC4
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Short name
anti-Caspase-12 Antibody ( )
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toCasp-12 (antibody to-) (large)
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Alternative technique
antibodies
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Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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