anti-LAL Antibody [9G7F12]

• Catalog number
  32-185
• Price
  Please ask
• Size
  0.1 mg

• Gene info
  Lysosomal acid lipase (LAL), with 378-amino acid protein( 43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.
• Gene names
  Cholesteryl esterase, Acid cholesteryl ester hydrolase, LAL, CESD
• Antibodie s label
  unlabelled serum
• Purity
  Antibody is purified by protein A affinity chromatography.
• Ab raised in
  Mouse
• Type
  Monoclonal
• Monoclonal
  9G7F12
• Immunoglobulin
  IgG2a
• Antigen
  Ni-NTA purified truncated recombinant LAL expressed in E. Coli strain BL21 (DE3).
• Immuno application
  ELISA, Western Blot
• Antibody advice
  Western Blot:Dilution 1:500 - 1:2,000 ELISA:Propose dilution 1:10,000.Determining optimal working dilutions by titration test.
• Suspention pH azide
  Purified antibody in PBS containing 0.03% sodium azide
• Keep at
  LAL monoclonal antibody can be stored at -20 grades C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  68067636
• Ncbi nr
  P38571
• NCBI GENE nr
  3988
• GENE symbol
  LIPA
• Antigene name
  lipase A, lysosomal acid, cholesterol esterase
• Source
  Homo sapiens
• Protein nr
  P38571
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LAL   [9G7F12]  
• Gene symbol
  LIPA
• Short name
  anti-LAL Antibody [9G7F12]
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toLAL (antibody to-) [9G7F12]
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6617
• Gene
  LIPA
• Long gene name
  lipase A, lysosomal acid type
• Synonyms gene name
  • lipase A, lysosomal acid, cholesterol esterase
• Synonyms
  • LAL
  • CESD
• Synonyms name
  • Wolman disease
  • lysosomal acid lipase
  • sterol esterase
• GenBank acession
  • M74775
• Locus
  10q23.31
• Discovery year
  1986-01-01
• Entrez gene record
  3988
• Pubmed identfication
  • 8432549
• RefSeq identity
  • NM_000235
• Classification
  • Lipases
• VEGA ID
  OTTHUMG00000018716

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products