-
Gene info
KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
-
Gene names
KCNN2, KCa2.2, SK2, SKCA2, hSK2, SKCa 2
-
Antibodie s label
unlabelled serum
-
Purity
Antibody is purified by peptide affinity chromatography method.
-
Ab raised in
Rabbit
-
Type
Polyclonal
-
Antigen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNN2.
-
Immuno application
ELISA, Western Blot
-
Antibody advice
KCNN2 antibody can be used for detection of KCNN2 by ELISA at 1:62500. KCNN2 antibody can be used for detection of KCNN2 by western blot at 1 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
-
Suspention pH azide
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
-
Keep at
For short periods of storage (days) store at 4 grades C. For longer periods of storage, store KCNN2 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.
-
Works with
Human, Mouse, Rat
-
Omim nr
25777647
-
Ncbi nr
NP_740721
-
KDa
26 kDa
-
Vial with antibody
Lyophilized
-
Quantity per ml
1 mg/ml
-
NCBI GENE nr
3781
-
GENE symbol
KCNN2
-
Antigene name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
-
Source
Homo sapiens
-
Protein nr
Q6PJI0
-
-
-
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translation
anticorps
