JARID2 polyclonal antibody
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Catalog number
6856-50
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Price
Please ask
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Size
50 μl
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Antibody Target
JARID2
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Target Alternative Name
JMJ
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Antibody Type
Polyclonal
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Species Reactivities
Human.
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Immunogen Sequence
Polyclonal antibody raised in rabbit against human JARID2 (jumonji, AT rich interactive domain 2) using two KLH conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively.
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Accession
Q92833
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Gene Id
3720
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Appearance
Colorless liquid
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Form
Liquid
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Formulation
In PBS with 0.05% (W/V) sodium azide.
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Purification
Whole Anti-Sera
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Application
ELISA.
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Positive Control
ELISA: Peptides.
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Application And Usages
ELISA: 1:500.
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Description
JARID2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. JARID2 acts by recruiting histone methyltransferase complexes (PRC2) to their target genes and modulating the histone methyltransferase activity. It does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of H3K27me3 by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating H3K9 methylation by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.
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Storage Condition
-20 °C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
Not Verified
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Immunocytochemistry Verified
Not Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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ELISA Verified
Verified
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ChIP Verified
Not Verified
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Dot Blot Verified
Not Verified
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Flow Cytometry Verified
Not Verified
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Group
Polyclonals and antibodies
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About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
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French translation
anticorps
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Gene target
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Gene symbol
JARID2-AS1, JARID2-DT, JARID2
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Short name
JARID2 polyclonal antibody
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Technique
Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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Isotype
Rabbit IgG
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Alternative name
jumonji, AT rich interactive domain 2 polyclonal (antibody to-)
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Alternative technique
polyclonals, antibodies
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Alternative to gene target
jumonji, AT rich interactive domain 2, JMJ, JARID2 and IDBG-62820 and ENSG00000008083 and 3720, protein binding, nuclei, Jarid2 and IDBG-147776 and ENSMUSG00000038518 and 16468, JARID2 and IDBG-636025 and ENSBTAG00000012938 and 528253
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Gene info
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Identity
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Gene
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Long gene name
JARID2 antisense RNA 1
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Synonyms gene name
- JARID2 antisense RNA 1 (non-protein coding)
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GenBank acession
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Locus
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Discovery year
2011-12-05
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Entrez gene record
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Classification
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VEGA ID
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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