anti-IRAK-4 Antibody

  • Catalog number
    3125
  • Price
    Please ask
  • Size
    0.02 mg, 0.1 mg
  • Gene info
    IRAK-4 Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kB and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
  • Gene names
    IRAK-4 Antibody: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64
  • Antibodie s label
    unlabelled serum
  • Purity
    IRAK-4 Antibody is affinity chromatography purified via peptide column.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Immunoglobulin
    IgG
  • Spicific to
    IRAK-4 antibody is predicted to not cross-react with other members of the IRAK protein family.
  • Antigen
    IRAK-4 antibody was made against a synthetic peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK-4.
  • Immuno application
    ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
  • Antibody advice
    IRAK-4 antibody can be used for the detection of IRAK-4 by Western blot at 1 to 4 ug/mL. Antibody can also be used for immunocytochemistry starting at 10 ug/mL. For immunofluorescence start at 10 ug/mL.
  • Suspention pH azide
    IRAK-4 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Keep at
    IRAK-4 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Works with
    Human
  • Omim nr
    20219010
  • Ncbi nr
    AAM15772
  • KDa
    Predicted: 51 kDa Observed: 51 kDa
  • Vial with antibody
    in solution
  • Quantity per ml
    1 mg/mL
  • NCBI GENE nr
    51135
  • GENE symbol
    IRAK4
  • Antigene name
    interleukin-1 receptor-associated kinase 4
  • Source
    Homo sapiens
  • Protein nr
    Q9NWZ3
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    IRAK-4  
  • Gene symbol
    IRAK3, IRAK1, IRAK4, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4
  • Short name
    anti-IRAK-4 Antibody
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toIRAK-4 (antibody to-)
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    interleukin 1 receptor associated kinase 3
  • Synonyms gene name
    • interleukin-1 receptor-associated kinase 3
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2002-07-17
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 18
  • Locus
    4
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 16
  • Locus
    4
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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