anti-IRAK-4 Antibody
-
Catalog number3125
-
PricePlease ask
-
Size0.02 mg, 0.1 mg
-
-
Gene infoIRAK-4 Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kB and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
-
Gene namesIRAK-4 Antibody: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64
-
Antibodie s labelunlabelled serum
-
PurityIRAK-4 Antibody is affinity chromatography purified via peptide column.
-
Ab raised inRabbit
-
TypePolyclonal
-
ImmunoglobulinIgG
-
Spicific toIRAK-4 antibody is predicted to not cross-react with other members of the IRAK protein family.
-
AntigenIRAK-4 antibody was made against a synthetic peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK-4.
-
Immuno applicationELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
-
Antibody adviceIRAK-4 antibody can be used for the detection of IRAK-4 by Western blot at 1 to 4 ug/mL. Antibody can also be used for immunocytochemistry starting at 10 ug/mL. For immunofluorescence start at 10 ug/mL.
-
Suspention pH azideIRAK-4 Antibody is supplied in PBS containing 0.02% sodium azide.
-
Keep atIRAK-4 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
Works withHuman
-
Omim nr20219010
-
Ncbi nrAAM15772
-
KDaPredicted: 51 kDa Observed: 51 kDa
-
Vial with antibodyin solution
-
Quantity per ml1 mg/mL
-
NCBI GENE nr51135
-
GENE symbolIRAK4
-
Antigene nameinterleukin-1 receptor-associated kinase 4
-
SourceHomo sapiens
-
Protein nrQ9NWZ3
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolIRAK3, IRAK1, IRAK4, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4
-
Short nameanti-IRAK-4 Antibody
-
TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
-
Alternative nameAntibody toIRAK-4 (antibody to-)
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 1 receptor associated kinase 3
-
Synonyms gene name
- interleukin-1 receptor-associated kinase 3
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2002-07-17
-
Entrez gene record
-
Pubmed identfication
-
Classification
- MicroRNA protein coding host genes
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 1 receptor associated kinase 1
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-06-22
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 1 receptor associated kinase 4
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2002-09-27
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1302-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1302 family
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 18
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 16
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-4
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 941-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNAs
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data