Anti-IL-1β (Canakinumab), Human IgG1 Antibody
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Catalog number
A2144-100
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Price
Please ask
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Size
100 µg
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Antibody Target
IL-1β
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Target Alternative Name
ACZ-885, ACZ885, Ilaris
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Antibody Type
Monoclonal
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Species Reactivities
Human
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Immunogen Sequence
Canakinumab
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Accession
DB06168
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
1 mg/ml
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Formulation
In PBS pH 7.5
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Purification
Protein A purified
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Description
Canakinumab is a recombinant human IgG1 kappa monoclonal antibody that is produced in murine Sp2/0-Ag14 cell line. This antibody binds to and neutralizes human IL-1β preventing association with its receptor and subsequent inflammatory signaling cascade. The antibody neither has cross-reactivity with IL-1α nor with the Interleukin 1 receptor, type I (IL1R1). Canakinumab was developed by Novartis to treat rheumatoid arthritis. It received FDA approval in 2009 to treat cryopyrin-associated periodic syndromes (CAPS). Additionally, in 2016, Canakinumab received approval for the treatment of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Hyperimmunoglobulinemia D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD) and Familial Mediterranean Fever (FMF). This antibody is marketed under the trade name Ilaris®.
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Storage Condition
-80ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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French translation
anticorps
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Gene target
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Gene symbol
IL1A, IL1B, IL1F10, IL36B, IL36A, IL19, IL17F, IL36G, IL25, IL22
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Short name
Anti-IL-1β (Canakinumab), IgG1 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
IgG1, kappa, IgG1
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Species
Humans
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Alternative name
Antibody toIL-1β (Canakinumab), H. sapiens IgG1 (antibody to-)
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
interleukin 1 alpha
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
interleukin 1 beta
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Synonyms
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GenBank acession
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Locus
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Discovery year
1989-03-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
Gene info
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Identity
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Gene
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Long gene name
interleukin 36 beta
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 8 (eta)
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
interleukin 36 alpha
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 6 (epsilon)
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
interleukin 19
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2000-03-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
interleukin 17F
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-03-18
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
interleukin 36 gamma
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 9
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
interleukin 25
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Synonyms gene
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Synonyms gene name
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Synonyms
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GenBank acession
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Locus
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Discovery year
2001-01-26
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Pubmed identfication
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
interleukin 22
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2001-03-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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