anti-IL-17B Receptor Antibody [97C691]
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Catalog number49-294
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PricePlease ask
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Size0.05 mg
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Gene infoRecently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis , multiple sclerosis , and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al and Lee, et al. and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain. IL17RB is a type I transmembrane protein with 17% homology to IL17R. Studies have shown that IL17RB binds strongly to IL17E, weakly to IL17B but does not bind IL17 or IL17C. The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8. Studies in a rat model of chemically induced IBD showed increased expression of IL17RB in the small intestine of treated rats.
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Gene namesIL17RB, CRL4, Cytokine receptor-like 4, EVI27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, IL-17RB, Interleukin 17 receptor B, IL17RH1, IL17BR, Interleukin 17B receptor, Interleukin-17B receptor, Cytokine receptor CRL4, IL-17Rh1, Interleukin-17 receptor B
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Antibodie s labelunlabelled serum
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PurityProtein G Column
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Ab raised inMouse
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TypeMonoclonal
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Monoclonal[97C691]
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ImmunoglobulinIgG1
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AntigenIL - 17B Receptor monoclonal antibody was made against full length IL - 17B Receptor (Human).
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Immuno applicationWestern Blot, immuno-histo-chemistry
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Antibody adviceIL-17B Receptor antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 10 ug/mL.
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Suspention pH azidePBS containing 0.05% BSA and 0.05% sodium azide
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Keep atIL-17B Receptor antibody should be stored long term (months) at -20 grades C and short term (weeks) at 4 grades C. As with all antibodies avoid freeze/thaw cycles.
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Works withBat, Gibbon, Gorilla, Horse, Human, Monkey, Pig
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Omim nr21263748
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Ncbi nrQ9NRM6
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Vial with antibodyin solution
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NCBI GENE nr55540
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GENE symbolIL17RB
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Antigene nameinterleukin 17 receptor B
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SourceHomo sapiens
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Protein nrQ9NRM6
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolIL17B, IL36G, IL25, IL22, IL18, IL37, IL6R, IL17C, IL17D, IL17A
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Short nameanti-IL-17B Receptor Antibody [97C691]
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toIL-17B Receptor (antibody to-) [97C691]
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameinterleukin 17B
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 36 gamma
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 9
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 25
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Synonyms gene
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Synonyms gene name
- interleukin 17E
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-01-26
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Pubmed identfication
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 22
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-03-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameinterleukin 18
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Synonyms gene name
- interleukin 18 (interferon-gamma-inducing factor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-07-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 37
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 7 (zeta)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 6 receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 17C
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 17D
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-05-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 17A
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Synonyms gene
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Synonyms gene name
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-10-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data